Cefotaxime
Summary
Hazard - P - B 0 T - Risk Cannot be excluded
Underlying information for P, B, T and risk are from Fass.
Fass environmental information
Fass environmental information for Cefotaxim Villerton (downloaded 2018-10-31).
Hazard
Persistence: No data.
Bioaccumulation: "Log P= -1.4 at neutral pH (predicted by ChemAxon)."
Toxicity: No data.
Risk
Risk of environmental impact of cefotaxime cannot be excluded, since no ecotoxicity data is available.
Article Predicted critical environmental concentrations for 500 pharmaceuticals
Critical effect concentration (CEC) for cefotaxime is 1 300 000 ng/L. Log P is set to 0.6.
Antibiotic resistance
Studies have shown that even low concentrations of antibiotics in the environment can contribute to antibiotic resistance and therefore as little as possible should end up in our environment.
For antibiotics in general, it is recommended that these drugs are used as restrictively as possible without risking the patient's health.
References
- Fass.se för vårdpersonal
- Fick J, Lindberg RH, Tysklind M, Larsson DG. Predicted critical environmental concentrations for 500 pharmaceuticals. Regul Toxicol Pharmacol. 2010;58:516-23.
- Bengtsson-Palme J, Larsson DG. Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation. Environ Int. 2016;86:140-9.
Author: Health and Medical Care Administration, Region Stockholm