Ceftriaxone

Detailed information

Fass environmental information

Fass environmental information for Rocephalin med lidokain (ceftriaxone, lidocaine) from Roche (downloaded 2024-10-08).

Hazard

Persistence: "Ceftriaxone disodium salt hemi(heptahydrate) is neither readily, nor inherently biodegradable. However, biodegradation in sewage sludge according to OECD 314 B showed a fast primary degradation of Ceftriaxone with cleavage of the beta-lactam ring, thereby demonstrating that the antibiotic activity is completely lost during sewage treatment. With a primary degradation DegT₅₀ of 0.43 days, this justifies the phrase 'Ceftriaxone disodium salt hemi(heptahydrate) is degraded in the environment.'"

Bioaccumulation: Log P_OW 0.025 pH 2.0 experimental, method unknown
log D -1.2 pH 7.4 experimental, method unknown
K_OC ≤ 2713 pH-sensitive, QSAR; low adsorption based on log P_ow  
BCF < 10 QSAR.

Chronic toxicity: There are data for 2 trophic levels, most sensitive cyanobacteria ErC₁₀ = 3.31 microg/L.

Risk

PEC/PNEC is based on sales data in Sweden in year 2021. "PNEC (μg/L) = lowest ErC₁₀/10, where 10 is the assessment factor used. An ErC₁₀ of 0.00331 mg/L (3.31 μg/L) for the cyanobacteria Anabaena flos-aquae has been used for this calculation. Fish has been considered not to be the relevant species, due to the low acute toxicity. This is a joint assessment performed by the AMR Industry Alliance. PNEC = 3.31 μg/L/10 =0.331 μg/L active substance."
PEC Predicted Environmental Concentration = 0.008 μg/L.
PEC/PNEC = 0.023 which gives the risk insignificant.

According to the guidelines AF 50 would be used for two long-term tests. PNEC = 3.31 μg/L/50 = 0.0662 μg/L. PEC/PNEC = 0.12 which gives the risk low.