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Ciclosporine

Summary

Persistence. Ciclosporine is degraded in the environment.

Bioaccumulation. Ciclosporine has low potential for bioaccumulation.

Toxicity. Ciclosporine has moderate acute toxicity.

Risk. The use of ciclosporine (sales data Sweden 2021) has been considered to result in insignificant environmental risk.

 

This summary information comes from fass.se.

Detailed information

Fass environmental information

Fass environmental information for Sandimmun (ciklosporine) from Novartis (dowloaded 2024-10-23).

Hazard

Persistence: "Ready degradability: 84.0 % degradation in 28 days, readily biodegradable (OECD301B). ... Ciclosporin has passed the criteria for ready biodegradation. Therefore, it can be classified as ciclosporin is degraded in the environment."

Bioaccumulation: Log Pow = 2.92 (experimentally determined, measured in octanol/water by centrifugal partition chromatography).

Acute toxicity: There are data for 3 trophic levels, most sensitive crustacean (Daphnia magna) EC50 48 h (immobilisation) 20200 microg/L.

Risk

PEC/PNEC is based on sales data in Sweden in year 2021. PEC/PNEC = 0.00073 which gives the risk insignificant.

Author: Health and Medical Care Administration, Region Stockholm