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Clobetasol propionate

Summary

Persistence. Clobetasol is potentially persistent.

Bioaccumulation. Clobetasol has low potential for bioaccumulation.

Toxicity. Clobetasol has very high acute toxicity.

Risk. The use of clobetasol (sales data Sweden 2016) has been considered to result in insignificant environmental risk.

 

This summary information comes from fass.se.

Detailed information

Fass environmental information

Fass environmental information for Dermovat (clobetasol propionate) (downloaded 2019-01-17)

Hazard

Persistence: "< 5% primary (removal of parent) degradation in 14 days (OECD 302). [---] Clobetasol propionate is not readily degradable or inherently biodegradable. The phrase “Clobetasol propionate is potentially persistent” is thus chosen."

Bioaccumulation: Log Pow = 3.49. "Since log Dow < 4 at pH 7, the substance has low potential for bioaccumulation."

Acute toxicity: There are data for 3 trophic levels, most sensitive fish (Oncorhyncus mykiss) EC50 for fish = 750 microg/L.

Risk

PEC/PNEC is based on sales data in Sweden in year 2016. PEC/PNEC = 0.00129 which gives the risk insignificant.

Author: Health and Medical Care Administration, Region Stockholm