Clobetasol propionate

Summary

Hazard 6 P 3 B 0 T 3 Risk Insignificant

The T-value in the score for hazard refers to acute toxicity. Underlying data for P, B, T and risk are from Fass.

Fass environmental information

Fass environmental information for Dermovat (clobetasol propionate) (downloaded 2019-01-17)

Hazard

Persistence: "< 5% primary (removal of parent) degradation in 14 days (OECD 302). [---] Clobetasol propionate is not readily degradable or inherently biodegradable. The phrase “Clobetasol propionate is potentially persistent” is thus chosen."

Bioaccumulation: Log P_ow = 3.49. "Since log D_ow < 4 at pH 7, the substance has low potential for bioaccumulation."

Toxicity: There are data for 3 trophic levels, most sensitive fish (Oncorhyncus mykiss) EC50 for fish = 750 microg/L.

Risk

PEC/PNEC is based on sales data in Sweden in year 2016. PEC/PNEC = 0.00129 which gives the risk insignificant.