Persistence. Clobetasone is potentially persistent.
Bioaccumulation. Clobetasone has low potential for bioaccumulation.
Toxicity. Clobetasone has very hig acute toxicity.
Risk. Risk of environmental impact cannot be excluded, since there is not sufficient ecotoxicity data available.
This summary information comes from Fass.
Fass environmental information for Emovat (clobetasone butyrate) from GlaxoSmithKline (downloaded 2022-06-21).
Persistence: "Ready degradability: No data. Inherent degradability: <20% degradation in 28 days, primary biodegradation (OECD 302B). [...] Clobetasone butyrate is not readily degradable or inherently degradable. The phrase “Clobetasone butyrate is potentially persistent” is thus chosen."
Bioaccumulation: Log Pow = 3.63 (TAD 3.02) ... Log Pow = 3.5.
Acute toxicity: There are data for 1 trophic level, Water flea (Daphnia magna): acute toxicity EC50 48 h (immobility) > 430 microg/L (TAD 3.11/OECD 202) ... NOEC = 430 microg/L.
"PNEC cannot be calculated because data is not available for all three (algae, crustacean and fish) of the toxicity endpoints." Risk of environmental impact cannot be excluded, since there is not sufficient ecotoxicity data available.
Author: Health and Medical Care Administration, Region Stockholm