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Clomipramine

Hazard 6* P 3 B 0 T 3* Risk See below

Information

The T-value in the score for hazard refers to acute toxicity. Underlying data for P, B and T are from Fass.

Fass environmental information

Fass environmental information for Anafranil (clomipramine) (downloaded date 2018-10-05).

Hazard

Persistence: "34 % degradation in 28 days, not readily biodegradable (OECD 301E). [---] According to the pass criteria for OECD301 studies, klomipramin can be classified as ‘Klomipramin is potentially persistent'."

Bioaccumulation: Log P = 2.1 (23°C, experimentally determined; method unknown).

Acute toxicity: There is data for 2 trophic levels, lowest fish (Danio rerio, zebrafish) 430 microg/L.

Risk

Sales data are presented in Sweden for 2016. "No PNEC can be calculated since there is not sufficient environmental toxicity data available, therefore the phrase "Risk of environmental impact of klomipramin cannot be excluded, since there is not sufficient ecotoxicity data available." is used."

Pharmaceutical analyses of water in Stockholm County and nationally respective in fish

Clomipramine has been found in purified wastewater at concentrations up to 3 ng/L in Stockholm County during the last five-year period (2012–2016) and in Swedish purified wastewater at concentrations up to 49 ng/L.

In the Swedish national screening programme, clomipramine levels have been found in fish up to 8.1 microg/kg.

Report Goodpoint 2018

Comparative assessment of environmental risk in the use of citalopram, escitalopram, sertraline, fluoxetine, venlafaxine, paroxetine and clomipramine in Sweden.

Overall, there is a risk profile for the studied antidepressants.

Clomipramine has been found in spiders

Clomipramine was one of the top 5 most frequently detected pharmaceuticals in spiders (article Richmond et al. 2018).

Author: Health and Medical Care Administration, Region Stockholm