The T-value in the score for hazard refers to chronic toxicity. Underlying data for P, B and T comes from Fass for Canesten (clotrimazole) (downloaded 2013-06-25). No new environmental information for clotrimazole is published on Fass.se (2018-09-05).
Fass environmental information for Canesten (clotrimazole) (downloaded 2013-06-25).
Persistence: "CO2 evolution test, guideline, C.4 C (6)). Test results 0% degradation in 28 days (guideline 79/831/EEC)."
Bioaccumulation: "Log Pow 4.1 (EU guideline 92/69/EC, A.8). Since log Pow 4.1, the substance has high potential for bioaccumulation."
Chronic toxicity: There is NOEC for 3 trophic levels, lowest NOEC for crustacean (Dapnia magna) 10 microg/L.
clotrimazole is not PBT/vPvB.
PEC/PNEC is based on sales data in Sweden in year 2011. PEC/PNEC = 0.013 which gives the risk insignificant.
Clotrimazole has been detected in treated wastewater and surface water in Stockholm County in the last five years (2012–2016). The average reduction rate was 96 %.
Clotrimazole has been detected in incoming and outgoing water from Swedish wastewater treatment plants.
Author: Health and Medical Care Administration, Region Stockholm