Clozapine
Summary
Hazard 9 P 3 B 3 T 3 Risk Low
The T-value in the score for hazard refers to acute toxicity. Underlying data for P, B, T and risk are from Leponex (clozapine) downloaded 2011-04-29. No new environmental information for clozapine is published on Fass.se (2018-09-04). It is voluntary for manufacturers to provide information about environmental impact on fass.se.
Fass environmental information
Fass environmental information for Leponex (downloaded 2011-04-29).
Hazard
Persistence: "3% (aerobic, 28d, 20-24°C,OECD 301B) not readily biodegradable."
Bioaccumulation: "log Kow 4.1 (Avdeef, 2003), log D 3.4 (pH 7, calculated using the Novartis internal Cheminformatics InSilico Profiling Tool, Novartis Institute of Biomedical Research, based on pKa and logP values; pKa1 = 3.52, pKa2 = 7.57)." The company's conclusion is that the substance has the potential to be stored in aquatic organisms.
Acute toxicity: There is data for 3 trophic levels, lowest for fish (Oncorhynchus mykiss) 710 microg/L.
Risk
PPEC/PNEC is based on sales data in Sweden in year 2010. PEC/PNEC = 0.13 which gives the risk low.
Pharmaceutical analyses of water in Stockholm County
Clozapine has previously been found in purified wastewater in Stockholm County (2005–2012). Clozapine has not been analyzed in recent years.
The report Pharmaceutial residues in the Stockholm aquatic environment
The reduction rate for clozapine in wastewater treatment plants in Stockholm County is between 28 and 49 %.
References
- Stockholms läns landsting. Miljöklassificerade läkemedel 2014–2015. Stockholm; 2014.
- Sammanställning av läkemedelsprovtagningar - Bearbetning av regional försäljningsstatistik av läkemedel samt datamaterial från Stockholms läns landstings mätprogram för läkemedelssubstanser i vattenmiljön, 2005-2012. Trossa AB På uppdrag av Stockholms läns landsting. 2014.
- Stockholm Vatten. Läkemedelsrester i Stockholms vattenmiljö. 2010. ISBN 978-91-633-6642-0.
Author: Health and Medical Care Administration, Region Stockholm