Deferoxamine
Summary
Persistence. Deferoxamine is degraded in the environment.
Bioaccumulation. Deferoxamine has low potential for bioaccumulation.
Toxicity. Deferoxamine may have low acute toxicity. The reported values are indicated as greater than and are not according to guidelines. The actual value may be lower.
Risk. Risk of environmental impact cannot be excluded, since there is not sufficient ecotoxicity data available.
This summary information comes from fass.se.
Detailed information
Fass environmental information
Fass environmental information for Desferal (Deferoxamine) from Novartis (accessed on 2025-05-15).
Hazard
Persistence: "Ready degradability: 69 % degradation in 28 days, readily biodegradable (OECD 301B) (Ciba-Geigy Project No. 90.2349) Justification of chosen degradation phrase: Deferoxamine passes the criteria for ready biodegradation. The phrase Deferoxamine is degraded in the environment is thus chosen."
Bioaccumulation: Log Kow < -3.0 (20 °C, method unknown). Log Kow = 2.62 (shake flask method) (Gotsbacher et al. 2017).
Toxicity: There are data for 2 trophic levels, most sensitive crustacean "EC50 48 h (immobilisation) > 100.0 mg/L (OECD 202)". Comment: Values reported as greater than are not according to the guidelines. The actual value may be lower.
Risk
"No PNEC can be calculated since there is only environmental toxicity data from two trophic levels available." Risk of environmental impact cannot be excluded, since there is not sufficient ecotoxicity data available.
References
Author: Health and Medical Care Administration, Region Stockholm