Hazard 4 P 3 B 0 T 1 Risk Low
The T-value in the score for hazard refers to chronic toxicity. Underlying data for P, B and T are from Fass. The risk comes from the report Goodpoint 2019.
Fass environmental information for Arcoxia (etoricoxib) from MSD (downloaded 2019-11-07).
Persistence: "No study has shown an appreciable degradation of etoricoxib. The phrase “Etoricoxib is potentially persistent” is thus chosen."
Bioaccumulation: Log Kow = 2.3 at pH 7 (OECD 107).
Chronic toxicity: There is NOEC for XX trophic levels, lowest NOEC for crustacean (Daphnia magna) 750 microg/L.
PEC/PNEC is based on sales data in Sweden in year 2015. PEC/PNEC = 0.001 which gives the risk insignificant.
Comparative assessment of environmental risk when using diclofenac, naproxen, ibuprofen, ketoprofen, etoricoxib, celecoxib and paracetamol from a Swedish perspective (Report Goodpoint 2019). From an environmental risk point of view, the exchange of diclofenac is recommended for any of the other investigated NSAIDs/analgesics. [...] Paracetamol is a very safe alternative from an environmental point of view. The others are also considered to pose low environmental risk, but slightly increased for ketoprofen. The risk factors for ketoprofen, naproxen, ibuprofen, celecoxib, etoricoxib and paracetamol are not considered so great that an exchange with another substance is recommended. Environmental measurements as well as efficacy studies of both celecoxib and etoricoxib are required."
Author: Health and Medical Care Administration, Region Stockholm