Persistence. Finasteride is potentially persistent.
Bioaccumulation. Finasteride has low potential for bioaccumulation.
Toxicity. Finasteride has high chronic toxicity.
Risk. The use of finasteride (sales data Sweden 2018) has been considered to result in insignificant environmental risk.
This summary information comes from Fass.
Fass environmental information
Fass environmental information for Finasterid STADA (finasterid) from Stada (downloaded 2023-04-13). The environmental information for finasteride is produced by the company MSD for Capipro, Proscar. However, these medical products from MSD have been withdrawn from the market.
Persistence: "Biotic degradation: Test results 0% degradation in 7 days based on CO2 evolution (i.e., no biodegradation) (FDA 3.11). Abiotic degradation: Hydrolysis: Test results 0% degradation in 5 days (US FDA 3.09). Photolysis: Test results 0% degradation over 8 days (US FDA 3.10)."
Bioaccumulation: "Log Kow = 3.56, 3.57 and 3.59 at pH 5, 7, 9, respectively (OECD 107)."
Chronic toxicity: There is NOEC for 3 trophic levels, lowest NOEC for fish (Oryzias latipes) 50 microg/L.
PEC/PNEC is based on sales data in Sweden in year 2018. PEC/PNEC = 0.005 which gives the risk insignificant.
Pharmaceutical analyses of water in Region Stockholm and nationally
Finasteride has been detected in surface water in Region Stockholm 2020 and has been detected up to 20 ng/L in purified wastewater nationally in Sweden.
Finasteride and spiders
Finasteride has been found in spiders (article Richmond et al. 2018).
- Fass.se för vårdpersonal
- IVL Swedish Environmental Research Institute Ltd. Fick J, Lindberg RH, Kaj L, Brorström-Lundén E. Results from the Swedish National Screening Programme 2010. Subreport 3, B 2014 Pharmaceuticals.
- Provtagningar av läkemedelsrester i vatten, sediment och fisk för Region Stockholm.
- Richmond EK, Rosi EJ, Walters DM, Fick J, Hamilton SK, Brodin T et al. A diverse suite of pharmaceuticals contaminates stream and riparian food webs. Nat Commun. 2018;9(1):4491.
Author: Health and Medical Care Administration, Region Stockholm