This summary information comes from Fass. Information on bioaccumulation and risk is supported by the report from Goodpoint.
Persistence. Furosemide is potentially persistent.
Bioaccumulation. Furosemide has low potential for bioaccumulation.
Toxicity. Furosemide has low acute toxicity.
Risk. The use of furosemide (sales data Sweden 2018) has been considered to result in insignificant environmental risk.
Persistence: Test results from "closed bottle test" (OECD guideline 301D) shows that the biological degradation is 0% in 28 days (Ref. 2). There is no information regarding the metabolites. Furosemide is potentially persistent.
Bioaccumulation: Log Kow ≤ 0 at pH 7, test method used to determine log K is a HPLC with C18 analytical column. Since log Kow < 4, the substance has low potential for bioaccumulation.
Toxicity: There are data for 3 trophic levels, most sensitive algae (Pseudokirchneriella subcapitata) EC50 72 h = 142000 microg/L.
PEC/PNEC is based on sales data in Sweden in year 2018. PEC/PNEC = 50,06 x 10–4 which gives the risk insignificant.
Persistence: No data.
Bioaccumulation: Log Kow = 2.03 at neutral pH (experimentally derived, method unknown). Since log Kow < 4 at pH 7, furosemide has low potential for bioaccumulation.
Toxicity: There are data for 3 trophic levels, most sensitive crustaceans (Daphnia magna): EC50 48 h (immobilization) = >100 000 microg/L. Comment: Values reported as greater than are not according to the guidelines. The actual value may be lower.
PEC/PNEC is based on sales data in Sweden in year 2016. PEC/PNEC = 0.0078 which gives the risk insignificant.
Furosemide has been found in purified wastewater, surface water and drinking water in Region Stockholm.
Large margin between concentrations in the environment and the concentration that affects the environment in Sweden. Furosemide has a low potential for bioaccumulation.
Author: Health and Medical Care Administration, Region Stockholm