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Gemfibrozil

Information

Environmental information is missing for gemfibrozil on fass.se (2021-04-15). It is voluntary for manufacturers to provide information about environmental impact on fass.se. This summary information on bioaccumulation, toxicity and risk comes from the report from Goodpoint.

Persistence. It cannot be excluded that gemfibrozil is persistent, due to the lack of data.
Bioaccumulation. All fibrates examined are fat soluble with a log P between 3.9 and 5.2. This is likely low enough for some to be found in soluble form in surface water, but at the same time high enough to bioconcentrate effectively.
Toxicity. Ecotoxicological studies are extensive for gemfibrozil and scarce for other fibrates. However, many studies are considered to be of low quality and reliability. Available and reliable efficacy data indicate a very low risk for all investigated fibrates.
Risk. The use of bezafibrate, fenofibrate and gemfibrozil is not considered to pose an environmental risk.

Detailed information

Report Goodpoint 2020

Comparative assessment of environmental risk when using the fibrates bezafibrate, fenofibrate and gemfibrozil from a Swedish perspective.

The three fibrates and the active metabolite fenofibratic acid are likely to occur in concentrations of single ng/L in Swedish aquatic environments exposed to treated municipal wastewater. A comparative assessment of the risk of receptor influence via the fish plasma model shows a very low risk for all substances studied. Ecotoxicological studies are extensive for gemfibrozil and scarce for other fibrates. However, many studies are considered to be of low quality and reliability. Available and reliable efficacy data indicate a very low risk for all investigated fibrates.

Recommendation

The use of bezafibrate, fenofibrate and gemfibrozil is not considered to pose an environmental risk. Therefore, no exchanges from an environmental risk point of view are recommended.

Author: Health and Medical Care Administration, Region Stockholm