Iohexol

Summary

Persistence. Iohexol is potentially persistent.

Bioaccumulation. Iohexol has low potential for bioaccumulation.

Toxicity. Iohexol has low acute toxicity.

Risk. The use of iohexol (sales data Sweden 2019) has been considered to result in insignificant environmental risk.

This summary information comes from fass.se.

Detailed information

Fass environmental information

Fass environmental information for Omnipaque (iohexol) from GE Healthcare (retrieved on 2025-07-09).

Hazard

Persistence: Iohexol showed no degradation in a 28-day OECD 301F test. Conclusion: The substance is potentially persistent.

Bioaccumulation: Iohexol has a log P_ow value of –0.5 (OECD 107), indicating a low potential for bioaccumulation.

Acute toxicity: There are data for 3 trophic levels, most sensitive fish LC₅₀ >1000 mg/L. Comment: Values reported as greater than are not according to the guidelines. The actual value may be lower.

Risk

PEC/PNEC is based on sales data in Sweden in year 2019.

PEC = 8,100189 microg/L.

PNEC = Lowest LC₅₀, >1000 mg/L/1000 (Assessment Factor (AF) for 3 acute studies) = 1000 microg/L.

PEC/PNEC = 0,0081 which gives the risk insignificant. (There is a discrepancy between the PEC value used in the PEC/PNEC ratio (5.6 µg/L) and the PEC value calculated earlier (8.1 µg/L).)

References

Fass för vårdpersonal.

Author: Health and Medical Care Administration, Region Stockholm