Iopromide

Detailed information

Fass environmental information

Fass environmental information for Ultravist (iopromide) from Bayer (retrieved on 2025-08-27).

Hazard

Persistence: Iopromide showed no biodegradation in the OECD 301E ready biodegradability test and only 23 % in the OECD 302B inherent biodegradability test, both below relevant thresholds. Simulation studies in sewage treatment systems demonstrated > 80 % elimination at high concentrations, but minimal degradation at environmentally relevant levels. Iopromide was also stable under hydrolysis conditions. Based on these results, iopromide is considered potentially persistent.

Bioaccumulation: The log D_ow was reported as ‑2.33.

Toxicity: There are data for 3 trophic levels, most sensitive crustacean NOEC ≥ 10000000 microg/L. Comment: Values reported as greater than are not according to the guidelines. The actual value may be lower.

Risk

PEC/PNEC is based on sales data in Sweden in year 2021.

PEC = 0.00508 microg/L.

PNEC = Lowest LC/EC₅₀, ≥ 10000000 microg/L/1000 (Assessment Factor (AF) for 3 acute studies) = 10000 microg/L. Comment in Fass: The PNEC was calculated based on the acute aquatic toxicity data since there was insufficient chronic aquatic toxicity data.

A NOEC value (OECD 211) has been reported, although ≥ 10,000 mg/L for crustaceans. An assessment factor (AF) of 100 could be applied according to the guidelines, but it would not affect the outcome for the risk classification.

PEC/PNEC = 5.08x10^-7 which gives the risk insignificant.