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Isosorbide mononitrate


Persistence. It cannot be excluded that isosorbide mononitrate is persistent, due to the lack of data.
Bioaccumulation. Isosorbide mononitrate has low potential for bioaccumulation.
Toxicity. Isosorbide mononitrate has moderate acute toxicity.
Risk. Risk of environmental impact cannot be excluded, since there is not sufficient ecotoxicity data available.


The data on hazard and risk are based on previous environmental information on fass.se from 2018. Environmental information is missing (2022-05-18). It is voluntary for manufacturers to provide information about environmental impact on fass.se.

Detailed information

Fass environmental information

Fass environmental information for Imdur (isosorbide mononitrate) from AstraZeneca (downloaded 2018-07-06).


Persistence: No data.

Bioaccumulation: Log P = 1.15. Metod QSAR – Log Kow: Log P = - 0.15.

Acute toxicity: There is data for 1 trophic level for crustaceans (Daphnia magna) EC50 > 120 mg/L. Comment: Value reported as greater than are not according to the guidelines. The actual value may be lower.


Sales in Sweden are available for 2014. "Since no long term effect data are available, and only short term data from one species, the water flea, is available, it is not possible to calculate the PNEC (Ref 1). Therefore, the statement "Risk of environmental impact of isosorbide mononitrate cannot be excluded, since there is not sufficient ecotoxicity data available" is used."

Pharmaceuticals residues in the aquatic environment in Sweden

Isosorbide mononitrate has been included in screening studies in Region Stockholm. Isosorbide mononitrate has also been included in national screening programs.

Author: Health and Medical Care Administration, Region Stockholm