Ketoprofen
Summary
Persistence. Ketoprofen is potentially persistent.
Bioaccumulation. Ketoprofen has low potential for bioaccumulation.
Toxicity. Ketoprofen has high chronic toxicity.
Risk. The use of ketoprofen (sales data Sweden 2018) has been considered to result in low environmental risk.
This summary information comes from Fass. According to the report from Goodoint 2016: Large margin between concentrations in the environment and the concentration that affects the environment from a Swedish perspective. However, ketoprofen appears to accumulate more in fish if exposure is effected through wastewater. The possibility is that the risk is underestimated.
Detailed information
Fass environmental information
Fass environmental information for Orudis (ketoprofen) from Sanofi AB (downloaded 2022-11-16).
Hazard
Persistence: "Ready degradability: Test showed 0% degradation in 29 days (protocol: ISO9439). Ketoprofen fails to pass the ready degradation test according to OECD criteria, which justifies the phrase “Ketoprofen is potentially persistent.”"
Bioaccumulation: Log Kow = 1.65 at pH 7 (protocol: OECD 107).
Acute toxicity: There is data for 3 trophic level, algae (Pseudokirchneriella subcapitata) 17.8 microg/L.
Risk
PEC/PNEC is based on sales data in Sweden in year 2018. PEC/PNEC = 0.13 which gives the risk low.
Pharmaceutial residues in the aquatic environment
Ketoprofen has been detected in treated wastewater in Region Stockholm during 2012–2016.
Report Goodpoint 2016
Large margin between concentrations in the environment and the concentration that affects the environment from a Swedish perspective. However, ketoprofen appears to accumulate more in fish if exposure is effected through wastewater. The possibility is that the risk is underestimated.
Report Goodpoint 2019
Comparative assessment of environmental risk when using diclofenac, naproxen, ibuprofen, ketoprofen, etoricoxib, celecoxib and paracetamol from a Swedish perspective (Report Goodpoint 2019). From an environmental risk point of view, the exchange of diclofenac is recommended for any of the other investigated NSAIDs/analgesics. [...] Paracetamol is a very safe alternative from an environmental point of view. The others are also considered to pose low environmental risk, but slightly increased for ketoprofen. The risk factors for ketoprofen, naproxen, ibuprofen, celecoxib, etoricoxib and paracetamol are not considered so great that an exchange with another substance is recommended. Environmental measurements as well as efficacy studies of both celecoxib and etoricoxib are required.
References
- Fass.se för vårdpersonal
- Provtagningar av läkemedelsrester i vatten, sediment och fisk för Region Stockholm.
- IVL Swedish Environmental Research Institute Ltd. Fick J, Lindberg RH, Kaj L, Brorström-Lundén E. Results from the Swedish National Screening Programme 2010. Subreport 3, B 2014 Pharmaceuticals.
- IVL Swedish Environmental Research Institute Ltd Fick J, Lindberg RH, Fång J, Magnér J, Kaj L, Brorström-Lundén E. Screening 2014. Analysis of pharmaceuticals and hormones in samples from WWTPs and receiving waters. Rapport C 135.
- Goodpoint. Prioritering av läkemedel med miljörisk inom SLL. Stockholm: Goodpoint; 2016. Rapport LS 2016–0634.
- Goodpoint. Jämförande bedömning av miljörisk vid användning av diklofenak, naproxen, ibuprofen, ketoprofen, etoricoxib, celecoxib samt paracetamol. Stockholm; Goodpoint; 2019.
Author: Health and Medical Care Administration, Region Stockholm