The T-value in the PBT index refers to acute toxicity.
Large margin between concentrations in the environment and the concentration that affects the environment. However, ketoprofen appears to accumulate more in fish if exposure is effected through wastewater. The possibility is that the risk is underestimated.
Ketoprofen has been detected in treated wastewater in Stockholm County in the last five years (2012–2016).
According to Fass.se, the lack of sufficient ecotoxicological data makes the environmental risk impossible to calculate. Therefore, risk of environmental impact can not be ruled out.
Comparative assessment of environmental risk when using diclofenac, naproxen, ibuprofen, ketoprofen, etoricoxib, and paracetamol in Sweden.
Log P for diclofenac from PubChem is reported to be 3.9–4.51. Available data clearly indicate that diclofenac represents the highest risk of the NSAID/analgesics investigated. The NSAIDs (ibuprofen, ketoprofen and naproxen) + paracetamol recommended in the Wise List are all better from an environmental point of view than diclofenac. Paracetamol is a very safe alternative from an environmental point of view. The others are also expected to cause a low environmental risk, somewhat elevated to ketoprofen.
Author: The Pharmaceutical unit of Region Stockholm