The data on hazard are based on previous environmental information on Fass.se.
Fass environmental information for lansoprazole from Actavis (downloaded 2019-10-25).
Persistence: No data.
Bioaccumulation: No data.
Toxicity: No data.
Risk of environmental impact of lansoprazole cannot be excluded since no ecotoxicity data are available.
Report Pharmaceutial residues in the Stockholm aquatic environment. Lansoprazole has been detected in outgoing water from wastewater treatment plants at concentrations between 1.1 and 1.4 ng/L.
Comparative assessment of environmental risk when using the gastric acid secretion inhibitors esomeprazole, lansoprazole, omeprazole, pantoprazole and ranitidine from a Swedish perspective (Report Goodpoint 2019).
Even if one assumes a "worst-case" exposure (PEC) or based on measured levels in environmental/wastewater (below detection limits except for ranitidine), the margins are against either CEC (risk of interaction with target species in aquatic organisms, especially fish) or against established toxicity levels in aquatic organisms very large (lower than 0.001 for all substances). Thus, the environmental risk is insignificant for all the investigated substances in Swedish water. No exchanges are therefore recommended from an environmental point of view.
Author: Health and Medical Care Administration, Region Stockholm