Leuprorelin
Summary
Persistence. The potential for persistence of leuprorelin acetate cannot be excluded, due to lack of data.
Bioaccumulation. Leuprorelin has low potential for bioaccumulation.
Toxicity. It cannot be excluded that leuprorelin is toxic, due to the lack of data.
Risk. Risk of environmental impact of leuprorelin acetate cannot be excluded, since no ecotoxicity data are available.
This summary information about leuprorelin comes from Fass.se.
Detailed information
Fass environmental information
Fass environmental information for Procren depot (leuprorelin) from AbbVie (downloaded 2024-03-18).
Hazard
Persistence: No data.
Bioaccumulation: "Log Dow = -1.7 at pH 7. The Kow of leuprolide acetate was reported to be 0.02 at pH of 7. [...] Since log Dow < 4 at pH 7, the substance has low potential for bioaccumulation."
Toxicity: No data.
Risk
"Risk of environmental impact of leuprorelin acetate cannot be excluded, since no ecotoxicity data are available."
Assessment report
Assessment report for Camcevi (leuprorelin), 24 March 2022, EMA/567396/2022.
"Leuprorelin is a synthetic nonapeptide, which is degraded to inactive peptide fragments prior to excretion in small amount in the urine. In line with EMEA/CHMP/SWP/4447/00 Rev. 1; leuprorelin is readily biodegradable and therefore it is not expected to pose a risk to the environment."
Author: Health and Medical Care Administration, Region Stockholm