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Hazard 5* P 3* B 0 T 2 Risk Low

The T-value in the score for hazard refers to acute toxicity. Underlying data for P, B, T and risk are from Fass.se.

Fass environmental information

Fass environmental information for levodopa from Sinemet (carbidopa, levodopa) (downloaded 2018-07-12).


Persistence: No data.

Bioaccumulation: Log Kow = -2.39.

Acute toxicity: There are data for 3 trophic, lowest for algae (Pseudokirchneriella subcapitata) = 1.5 mg/L.


PEC/PNEC is based on sales data in Sweden in year 2016. PEC/PNEC = 0.43 which gives the risk low.

Assessment report

Assessment report for Numient (carbidopa, levodopa) 24 September 2015, EMA/CHMP/672104/2015. "Levodopa is a natural substance, the use of which will not alter the concentration or distribution of the substance in the environment. Therefore, levodopa is not expected to pose a risk to the environment."

Author: Health and Medical Care Administration, Region Stockholm