Levomepromazine
Summary
Persistence. Levomepromazine is potentially persistent.
Bioaccumulation. Levomepromazine has low potential for bioaccumulation.
Toxicity. Levomepromazine has very high acute toxicity.
Risk. Risk of environmental impact of Levomepromazine cannot be excluded, since there is not sufficient data to calculate a PEC/PNEC ratio.
This summary information comes from fass.se.
Detailed information
Fass environmental information
Fass environmental information for Nozinan (levomepromazine) (downloaded 2018-11-01).
Hazard
Persistence: "Test showed 13% degradation in 28 days (ISO 9439). [---] Levomepromazine fails to pass the criteria for ready biodegradability which justifies the phrase “levomepromazine is potentially persistent”."
Bioaccumulation OECD 107: log Kow at pH 7 = 0.38.
Acute toxicity: Data available for 1 trophic level for crustaceans (Daphnia magna) 700 microg/L.
Risk
"Risk of environmental impact of Levomepromazine cannot be excluded, since there is not sufficient data to calculate a PEC/PNEC ratio."
Pharmaceutical analyses of water in Sweden
Levomepromazine has been included in screening programs both regionally within the Stockholm area and nationally in Sweden but has been below the LOQ (quantitative limit value).
References
- Fass.se för vårdpersonal
- Fick J, Lindberg RH, Tysklind M, Larsson DG. Predicted critical environmental concentrations for 500 pharmaceuticals. Regul Toxicol Pharmacol. 2010;58:516-23.
- IVL Swedish Environmental Research Institute Ltd. Fick J, Lindberg RH, Kaj L, Brorström-Lundén E. Results from the Swedish National Screening Programme 2010. Subreport 3, B 2014 Pharmaceuticals.
- IVL Swedish Environmental Research Institute Ltd Fick J, Lindberg RH, Fång J, Magnér J, Kaj L, Brorström-Lundén E. Screening 2014. Analysis of pharmaceuticals and hormones in samples from WWTPs and receiving waters. Rapport C 135.
Author: Health and Medical Care Administration, Region Stockholm