Hazard 6* P 3 B 0 T 3* Risk Cannot be excluded
The T-value in the score for hazard refers to acute toxicity. Underlying data for P, B, T and risk are from Fass.
Fass environmental information
Fass environmental information for Nozinan (levomepromazine) (downloaded 2018-11-01).
Persistence: "Test showed 13% degradation in 28 days (ISO 9439). [---] Levomepromazine fails to pass the criteria for ready biodegradability which justifies the phrase “levomepromazine is potentially persistent”."
Bioaccumulation OECD 107: log Kow at pH 7 = 0.38.
Acute toxicity: Data available for 1 trophic level for crustaceans (Daphnia magna) 700 microg/L.
"Risk of environmental impact of Levomepromazine cannot be excluded, since there is not sufficient data to calculate a PEC/PNEC ratio."
Pharmaceutical analyses of water
Levomepromazine has been included in screening programs both regionally within the Stockholm area and nationally but has been below the LOQ (quantitative limit value).
- Fass.se för vårdpersonal
- Fick J, Lindberg RH, Tysklind M, Larsson DG. Predicted critical environmental concentrations for 500 pharmaceuticals. Regul Toxicol Pharmacol. 2010;58:516-23.
- IVL Swedish Environmental Research Institute Ltd. Fick J, Lindberg RH, Kaj L, Brorström-Lundén E. Results from the Swedish National Screening Programme 2010. Subreport 3, B 2014 Pharmaceuticals.
- IVL Swedish Environmental Research Institute Ltd Fick J, Lindberg RH, Fång J, Magnér J, Kaj L, Brorström-Lundén E. Screening 2014. Analysis of pharmaceuticals and hormones in samples from WWTPs and receiving waters. Rapport C 135.
Author: Health and Medical Care Administration, Region Stockholm