Lumefantrine

Summary

Persistence. Lumefantrine is potentially persistent.

Bioaccumulation. Lumefantrine has low potential for bioaccumulation.

Toxicity. Lumefantrine has high acute toxicity. See comment under the heading "Detailed Information".

Risk. The use of lumefantrine (sales data Sweden 2023) has been considered to result in insignificant environmental risk.

This summary information comes from fass.se.

Detailed information

Fass environmental information

Fass environmental information lumefantrine from Riamet (artemether, lumefantrine) from Novartis (retrieved on 2025-10-28).

Hazard

Persistence: "Biotic degradation. Ready degradability: 4.0 % degradation in 29 days, not readily biodegradable (OECD301B)."

Bioaccumulation: Log P_ow = 2.29–3.52 (experimentally determined) (Kotila et al. 2013).

Acute toxicity: There are data for 3 trophic levels, most sensitive fish LC₅₀ > 5000 microg/L. Comment: Values reported as greater than are not according to the guidelines. The actual value may be lower.

Risk

PEC/PNEC is based on sales data in Sweden in year 2023.

PEC = 0.000097 microg/L.

PNEC = Lowest LC₅₀ > 5000 microg/L/1000 (Assessment Factor (AF) for 3 acute studies) = 5 microg/L

PEC/PNEC = 0.00001933 which gives the risk insignificant.

Author: Health and Medical Care Administration, Region Stockholm