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Persistence. Macrogol is degraded in the environment.

Bioaccumulation. Macrogol has low potential for bioaccumulation.

Toxicity. Macrogol has low chronic toxicity.

Risk. The use of macrogol (sales data Sweden 2018) has been considered to result in low environmental risk.

This summary information comes from Fass.

Detailed information

Fass environmental information

Fass environmental information for Movicol (potassium chloride, macrogol, sodium chloride, sodium bicarbonate) from Norgine (downloaded 2023-01-23).


Persistence: "Mixtures containing PEG 3350 were 10% of the theoretical maximum after 4 days, 60% after 7 days and 96% at the end of the test (Day 28). Substances are considered to be readily biodegradable in this test if CO2 production is equal to or greater than 60% of the theoretical value within ten days of the level achieving 10%. [...] The phrase “Macrogol 3350 (PEG 3350) is degraded in the environment” is thus chosen."

Bioaccumulation: Log10 Kow of PEG 3350 (macrogkol 3350) was <1.0.

Toxicity: There are data for 3 trophic levels, most sensitive crustacean (Daphnia magna) NOEC 9 500 microg/L.


PEC/PNEC is based on sales data in Sweden in year 2018. PEC/PNEC = 0.11 which gives the risk low.

Author: Health and Medical Care Administration, Region Stockholm