Medroxyprogesterone acetate
Summary
Persistence. No data.
Bioaccumulation. No data.
Toxicity. No data.
Risk. See the report from Goodpoint.
Environmental information is missing on fass.se for medroxyprogesterone acetate (2020-01-18). It is voluntary for manufacturers to provide information on environmental impact on fass.se.
Detailede information
Report from Goodpoint
Based on the ability to bind to the androgen receptor, bind to SHBG (Sex Hormone Binding Globulin) and studies on fish make medroxyprogesterone a much lower environmental risk than levonorgestrel and norethisterone. The ability of a substance to activate the androgen receptor in fish probably contributes to increased risk of environmental impact, and binding to SHBG is believed to contribute to increased bioconcentration (and thus potency) in fish.
References
- Miljöhänsyn vid förskrivning av gestagena preparat. Joakim Larsson/Goodpoint, 2017-06-26.
- Miguel-Queralt S, Hammond GL. Sex hormone-binding globulin in fish gills is a portal for sex steroids breached by xenobiotics. Endocrinology. 2008;149:4269-75.
- Zeilinger J, Steger-Hartmann T, Maser E, Goller S, Vonk R, Länge R. Effects of synthetic gestagens on fish reproduction. Environ Toxicol Chem. 2009;28:2663-70.
- Fick J, Lindberg RH, Parkkonen J, Arvidsson B, Tysklind M, Larsson DG. Therapeutic levels of levonorgestrel detected in blood plasma of fish: results from screening rainbow trout exposed to treated sewage effluents. Environ Sci Technol. 2010;44:2661-6.
Author: Health and Medical Care Administration, Region Stockholm