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Mercaptopurine

Summary

Persistence. It cannot be excluded that mercaptopurine is persistent, due to the lack of data.

Bioaccumulation. Mercaptopurine has low potential for bioaccumulation.

Toxicity. It cannot be excluded that mercaptopurine is toxic, due to the lack of data.

Risk. Risk of environmental impact of mercaptopurine cannot be excluded, due to the lack of environmental toxicity data.

 

This summary information comes from fass.se with the exception of bioaccumulation which comes from the assessment report.

Detailed information

Assessment report

Assessment report for Xaluprine (previously Mercaptopurine Nova Laboratories) 21 July 2011, EMA/CHMP/668488/2011.

Hazard

Persistence: Lack of data.

Bioaccumulation: Log Kow = 0.71; -0.17 at pH 5.7 and – 0.37 at pH 7.4; 0.01 at pH 7.4. "The log partition coefficient in octanol/water (log Kow) values of 6-mercaptopurine is < 4.5, such that this drug substance does not present any hazards with respect to bioaccumulation and persistence." However, no data for persistence can be found in the assessment report.

Toxicity: Lack of data.

Risk

"PECsurfacewater values for 6-mercaptopurine has been calculated to be 0.00116 μg/L. This value is nearly 10 times lower than the action limit of 0.01 μg/L. Therefore, Phase II environmental fate and effects assessments were not considered necessary, which is acceptable and in line with the aforementioned guideline."

Fass environmental information

Fass environmental information for Puri-nethol (mercaptopurine) from Aspen Nordic (dowloaded 2025-01-14).

Hazard

Persistence: Lack of data.

Bioaccumulation: Lack of data.

Toxicity: Lack of data.

Risk

Risk of environmental impact of mercaptopurine cannot be excluded, due to the lack of environmental toxicity data.

Author: Health and Medical Care Administration, Region Stockholm