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Methylphenidate

Hazard 5* P 3* B 0 T 2 Risk Insignificant

Information

The T-value in the score for hazard refers to acute toxicity. Underlying data for B comes from Fass environmental information for Concerta (methylphenidate) downloaded 2018-09-04. Underlying data for P comes from Fass environmental information for Ritalin (methylphenidate) downloaded 2011-05-27. Underlying data for T comes from Fass environmental information for Concerta downloaded 2011-05-27. The risk is calculated on the basis of data for the PNEC value from Concerta's environmental information downloaded 2011-05-27 and the reported PEC value from Fass environmental information for Concerta downloaded 2018-09-04 when in Fass environmental information for Concerta downloaded 2018-09-04 it is stated that the risk of environmental effects of methylphenidate can not be excluded when no ecotoxicological data are available.

Fass environmental information

Hazard

Persistence according to Fass environmental information for Ritalin downloaded 2011-05-27: "Degradation: 4% (aerobic, OECD 301E) not readily biodegradable."

Bioaccumulation according to Fass environmental information for Concerta downloaded 2018-09-04: log Dow = 0.2.

Acute toxicity according to Fass environmental information for Concerta downloaded 2011-05-27: Data for 3 trophic levels, lowest for green algae (Selenastrum capricornutum) 6 mg/L.

Risk

PEC/PNEC is based on sales data in Sweden in year 2016 according to Fass environmental information for Concerta downloaded 2018-09-04. PEC = 0.15029664 microg/L. PNEC (Fass environmental information for Concerta downloaded 2011-05-27) = 6 mg/L/1000 (AF) = 6 microg/L. PEC/PNEC = 0,025 which gives the risk insignificant.

Author: Health and Medical Care Administration, Region Stockholm