Persistence. Metoclopramide is potentially persistent.
Bioaccumulation. Metoclopramide has low potential for bioaccumulation.
Toxicity. Metoclopramide has moderate acute toxicity.
Risk. The use of metoclopramide (sales data Sweden 2019) has been considered to result in insignificant environmental risk.
This summary information comes from Fass.
Fass environmental information
Fass environmental information for Primperan (metoclopramide) from Sanofi (downloaded 2022-12-21).
Persistence: Ready degradability 0 % in 28 days Guideline: OECD 301F.
Bioaccumulation: "Log P = 2.667 (experimentally derived, method unknown, pH unknown)."
Toxicity: There are data for 3 trophic levels, most sensitive algae EC50 35 600 microg/L.
PEC/PNEC is based on sales data in Sweden in year 2019. PEC/PNEC = 0.00042 which gives the risk insignificant.
Author: Health and Medical Care Administration, Region Stockholm