The T-value in the score for hazard refers to acute/chronic toxicity. Underlying data for P, B and T comes from Fass.
Fass environmental information for Daktacort (hydrocortisone, miconazole) for miconazole (downloaded 2018-06-27).
Persistence: "Miconazole nitrate is potentially persistent."
Bioaccumulation: BCF = 1 949.
Chronic toxicity: There is NOEC for 3 trophic levels, lowest NOEC for green algae (Selenastrum capricornutum) NOECr 72 h = 10 microg/L.
PEC/PNEC is based on sales data in Sweden in year 2015. PEC/PNEC = 0.3455 which gives the risk low.
In selection of algae for toxicity testing of antimicrobials the European Medicines Agency, EMA, recommends test on blue-green algae (cyanobacteria). No information on toxicity on blue-green algae has been found, which means that a calculation of environmental risk becomes uncertain.
Author: Health and Medical Care Administration, Region Stockholm