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Miconazole

Hazard 8 P 3 B 3 T 2 Risk Low

Information

The T-value in the score for hazard refers to acute/chronic toxicity. Underlying data for P, B and T comes from Fass.

Fass environmental information

Fass environmental information for Daktacort (hydrocortisone, miconazole) for miconazole (downloaded 2018-06-27).

Hazard

Persistence: "Miconazole nitrate is potentially persistent."

Bioaccumulation: BCF = 1 949.

Chronic toxicity: There is NOEC for 3 trophic levels, lowest NOEC for green algae (Selenastrum capricornutum) NOECr 72 h = 10 microg/L.

Risk

PEC/PNEC is based on sales data in Sweden in year 2015. PEC/PNEC = 0.3455 which gives the risk low.

In selection of algae for toxicity testing of antimicrobials the European Medicines Agency, EMA, recommends test on blue-green algae (cyanobacteria). No information on toxicity on blue-green algae has been found, which means that a calculation of environmental risk becomes uncertain.

Author: Health and Medical Care Administration, Region Stockholm