Naratriptan
Summary
Persistence. Naratriptan is potentially persistent.
Bioaccumulation. Naratriptan has low potential for bioaccumulation.
Toxicity. Naratriptan has moderate acute toxicity.
Risk. The use of naratriptan (sales data Sweden 2022) has been considered to result in insignificant environmental risk.
This summary information comes from fass.se.
Detailed information
Fass environmental information
Fass environmental information for Naramig (naratriptan) from GlaxoSmithKline (retrieved on 2025-11-26).
Hazard
Persistence: For naratriptan, biotic degradation studies showed that the substance is not readily biodegradable (<1% in 28 days, TAD 3.11) and not inherently biodegradable (3% ultimate DOC (Dissolved Organic Carbon) removal and 27% primary degradation in 28 days, OECD 302). In soil, 3–36% degradation was observed over 64 days (OECD 304). Abiotic degradation via hydrolysis indicated 50% degradation at 25 °C only after more than one year at pH 7 (TAD 3.09), while no data were available for photolysis. Overall, naratriptan is considered neither readily nor inherently biodegradable and is therefore described as potentially persistent.
Bioaccumulation: Log Dow = -0.62 at pH 7 (TAD 3.02).
Acute toxicity: There are data for 3 trophic levels, most sensitive algae NOEC 100000 microg/L.
Risk
PEC/PNEC is based on sales data in Sweden in year 2022.
PEC = 0.00000795 microg/L.
PNEC = Lowest NOEC, 100000 microg/L/1000 (Assessment Factor (AF) for 3 acute studies) = 100 microg/L.
PEC/PNEC = 7.95 x 10-8 which gives the risk insignificant.
References
Author: Health and Medical Care Administration, Region Stockholm