Hazard 6* P 3 B 0 T 3* Risk Insignificant
Measurements of nomegestrol in the environment are lacking, but the substance binds weakly to both the androgen receptor and SHBG (Sex Hormone Binding Globulin), which gives a low risk profile. The ability of a substance to activate the androgen receptor in fish is believed to contribute to increased risk of environmental impact. Binding to SHBG is believed to contribute to increased bioconcentration (and thus potency) in fish.
The risk classification insignificant, according to Fass.se, is based on total sold amount (kg) of the substance in Sweden during the year 2015 and the toxicity of the substance.
Author: Health and Medical Care Administration, Region Stockholm