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Hazard 4 P 3 B 0 T 1 Risk Insignificant


The T-value in the score for hazard refers to acute toxicity. Underlying data for P, B and T comes from Fass.se. Esomeprazole is the S-enantiomer of the racemate omeprazole. See also esomeprazole.

Fass environmental information

Fass environmental information for Losec (omeprazole) (downloaded 2018-07-03).


Persistence: "Omeprazole has been shown to undergo rapid abiotic degradation across the environmentally relevant pH range, with an abiotic half-life of <40 days. However, based on the data above (considering no other data is available), the substance has been assigned the risk phrase "Omeprazole is potentially persistent"."

Bioaccumulation: Log D = 2.24.

Acute toxicity: There are data for 3 trophic levels, lowest for fish (Danio rerio) 41.9 mg/L (OECD 203).


PEC/PNEC is based on sales data in Sweden in year 2015. PEC/PNEC = 0.018 which gives the risk insignificant.

Pharmaceutial residues in the aquatic environment

Omeprazole has previously been found in purified wastewater in Stockholm County (2005–2012). Omeprazole has not been analyzed in recent years.

Report Pharmaceutial residues in the Stockholm aquatic environment. Omeprazole has been detected in purified wastewater and in drinking water.

Author: The Pharmaceutical unit of Region Stockholm