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Kommersiellt obunden läkemedelsinformation riktad till läkare och sjukvårdspersonal

Orphenadrine

Summary

Persistence. It cannot be excluded that orphenadrine is persistent, due to lack of data.

Bioaccumulation. Orphenadrine has low potential for bioaccumulation.

Toxicity. Orphenadrine has high acute toxicity.

Risk. Risk of environmental impact of orphenadrine cannot be excluded, since there is not sufficient ecotoxicity data available.

 

This summary information comes from fass.se.

Detailed information

Fass environmental information

Fass environmental information for Norflex (orphenadrine) from Viatris AB (retrieved on 2026-02-19).

Hazard

Persistence: No data.

Bioaccumulation: Log Kow = 3.77 (unknown method).

Acute toxicity: There are data for 2 trophic levels, most sensitive crustacean EC50 8870 microg/L.

Risk

PEC/PNEC is based on sales data in Sweden in year 2023.

PEC = 0.034 microg/L.

Risk of environmental impact of orphenadrine cannot be excluded, since there is not sufficient ecotoxicity data available.

Pharmaceuticals residues in the aquatic environment in Region Stockholm

Orphenadrine was previously included among the substances monitored in Region Stockholm, Sweden, and during the 2021 measurement the compound was detected in the treated wastewater effluent.

Orphenadrine has been detected in caddisfly larvae

Orphenadrine has been detected in caddisfly larvae, as reported by Richmond et al. (2018).

References

  1. Fass.se för vårdpersonal.
  2. Provtagningar av läkemedelsrester i vatten, sediment och fisk för Region Stockholm.
  3. Richmond EK, Rosi EJ, Walters DM, Fick J, Hamilton SK, Brodin T et al. A diverse suite of pharmaceuticals contaminates stream and riparian food webs. Nat Commun. 2018;9(1):4491.

Author: Health and Medical Care Administration, Region Stockholm