This summary information on persistence, biockumulation and toxicity comes from Fass. The risk comes from the Goodpoint report.
Persistence. Oxcarbazepine is potentially persistent.
Bioaccumulation. Oxcarbazepine has low potential for bioaccumulation.
Toxicity. Oxcarbazepine has moderate acute toxicity.
Risk. No obvious environmental risk from a Swedish perspective.
Fass environmental information
Fass environmental information for Trileptal (oxkarbazepine) from Novartis (downloaded 2021-04-14).
Persistence: "2.0 % degradation in 28 days, not readily biodegradable (OECD 301E). [...] Oxcarbazepine does not pass the criteria for ready biodegradability. Therefore, the phrase ‘Oxcarbazepine is potentially persistent’ is used."
Bioaccumulation: Log D (at pH 7.4) = 1.31 (experimentally determined, method unknown).
Toxicity: There are data for 3 trophic levels, most sensitive algae "ErC50 72 h (growth rate)" = 12800 microg/L.
PEC/PNEC is based on sales data in Sweden in year 2018. PEC/PNEC = 0.0135 which gives the risk insignificant.
Report Goodpoint 2020
Comparative assessment of environmental risk when using antiepileptics: lamotrigine, levetiracetam, oxcarbazepine, topiramate and zonisamide from a Swedish perspective.
Although lamotrigine is linked to a slightly higher risk than other substances (based on higher fat solubility), there is no obvious environmental risk for any of the substances. Therefore, no exchanges from an environmental risk point of view are recommended. Measurements of lamotrigine in Swedish wastewater/biota are recommended.
Author: Health and Medical Care Administration, Region Stockholm