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This summary information on bioaccumulation and toxicity comes from Fass (Panocod). The information on persistence comes from previous environmental information in Fass (Alvedon forte). The risk comes from the report by Goodpoint. Data on bioaccumulation are also supported by the report from Goodpoint.


Persistence. Paracetamol is not considered to be persistent.
Bioaccumulation. Paracetamol has low potential for bioaccumulation.
Toxicity. Paracetamol has moderat chronic toxicity.
Risk. The use of paracetamol has been considered to result in insignificant environmental risk.

Detailed information

Fass environmental information for Panocod

Fass environmental information for Panocod (codeine, paracetamol) from Sanofi AB (downloaded 2021-06-28).


Persistence: No data.

Bioaccumulation: Log P = 0.91 (pH unknown, predicted, Chem Axon).

Toxicity: There are data for 3 trophic levels, most sensitive crustacean (Daphnia magna) NOEC 100 microg/L.


PEC/PNEC is based on sales data in Sweden in year 2018. PEC/PNEC = 9.848 which gives the risk moderate.

Fass environmental information for Alvedon forte

Fass environmental information for Alvedon forte (paracetamol) from GlaxoSmithKline Consumer Healthcare AB (downloaded 2018-09-24).


Persistence: "Results of biological degradation: Inherent biodegradation = 99% in 5 days (OECD 302B, IUCLID data set). The substance is inherently biodegradable. The material is expected to be highly removed in wastewater treatment plants, 98% removal (Reference 9). This is supported by a measured biodegradation constant of 58–80 L g-1 d in a WWTP simulation test (Reference 6). Biodegradation constants greater than 10 are expected to result in greater than 90% biodegradation. Additionally, a DT50 of 3.1d and a DT90 of 10d was measured (Reference 8) using a water-sediment study (OECD 308) indicating a low potential for persistence. The phrase ‘Paracetamol is slowly degraded in the environment’ is thus chosen." According to expert, paracetamol is not considered to be persistent based on this data from Fass environmental information (Researcher at the Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University (2019-11-06). 

Bioaccumulation: Log Pow = 0.51 at pH 7 (OECD 107).

Acute toxicity: There is data for 3 trophic levels, lowest for algae (Scenedesmus subspicatus) 9 200 microg/L.


PEC/PNEC is based on sales data in Sweden in year 2014. PEC/PNEC = 0.196 which gives the risk low.

Pharmaceutial residues in the aquatic environment

Studies from several Swedish wastewater treatment plants showed that paracetamol was reduced with up to 99%. Concentrations of paracetamol detected in a gradient from the inner city of Stockholm into the archipelago are up to 6.6 ng/L. Paracetamol has been found in surface water within Region Stockholm in 2018 at concentrations up to 200 ng/L.

Paracetamol has also been measured in drinking water in the Stockholm area at concentrations up to 15 ng/L (The report from IVL and drug analysis in Region Stockholm).

Report Goodpoint 2019

Comparative assessment of environmental risk when using diclofenac, naproxen, ibuprofen, ketoprofen, etoricoxib, celecoxib and paracetamol from a Swedish perspective (Report Goodpoint 2019). From an environmental risk point of view, exchanging diclofenac for any of the other investigated NSAIDs/analgesics is recommended. [...] Paracetamol is a very safe alternative from an environmental point of view. The other APIs are also considered to pose low environmental risk, but slightly increased for ketoprofen. The risk factors for ketoprofen, naproxen, ibuprofen, celecoxib, etoricoxib and paracetamol are not considered so great that an exchange with another substance is recommended. Environmental measurements as well as efficacy studies of both celecoxib and etoricoxib are required."

Author: Health and Medical Care Administration, Region Stockholm