The T-value in the score for hazard refers to acute toxicity. Underlying data for P, B and T are from Fass.
Fass environmental information for Seroxat (paroxetine) (downloaded 2018-10-01).
Persistence: "Ready degradability: <1% degradation in 28 days (TAD 3.11). [---] Primary metabolite (BRL36610): 50% primary degradation in 23 hrs. [---] Paroxetine is not readily degradable or inherently degradable. This substance degrades rapidly via photlysis but fate and effects data is not available for photo degradents. The phrase “paroxetine is potentially persistent in the environment” is thus chosen."
Bioaccumulation: Log Dow at pH 7 = 1.30.
Acute toxicity: There are data for 3 trophic levels, lowest for green algae (Scenedesmus subspicatus) "IC50 96h (growth)" = 140 microg/L.
PEC/PNEC is based on sales data in Sweden in year 2016. PEC/PNEC = 0.2 which gives the risk low.
Pharmaceutical analyses of water and fish
Paroxetine has been detected in purified wastewater, surface and drinking water. In the Swedish surveillance program, paroxetine was detected up to 44 ng/L in single samples of purified wastewater.
Paroxetine has been found in wild Swedish fish, perch, at a concentration of 17 microg/kg.
Comparative assessment of environmental risk in the use of citalopram, escitalopram, sertraline, fluoxetine, venlafaxine, paroxetine and clomipramine in Sweden (Report Goodpoint 2018). Overall, there is a risk profile for the studied antidepressants.
Author: The Pharmaceutical unit of Region Stockholm