Kommersiellt obunden läkemedelsinformation riktad till läkare och sjukvårdspersonal

Prednisone

Hazard - P - B 0 T - Risk Cannot be excluded

Information

Prednisone is converted in the body to prednisolone via a reversible reaction.

The data on B is based on previous environmental information on fass.se. Environmental information is missing (2020-01-16). It is voluntary for manufacturers to provide information about environmental impact on fass.se.

Fass environmental information

Fass environmental information for Deltison (prednisone) from Recip (downloaded 2013-07-02).

Hazard

Persistence: No data.

Bioaccumulation: "The log Kow for prednisone is 1.42, and a BCF value has been estimated to 2,7. This doesn’t indicate any significant bioaccumulation potential for prednisone."

Toxicity: "No EC50 value for Daphnia magna value could be calculated for prednisolone, with 85 mg/l not resulting in any effect. Similarily no LC50 value for Thamnocephalus platyurus could be calculated. For Brachionus calyciflorus the LC50 value was 22,29 mg/l (22290 microg/l). In a long term toxicity test (7 days test, ISO 2001) a prednisolone concentration of 0,23 mg/l (230 microg/l) caused 50 % population growth inhibition for Ceriodaphnia dubia."

Risk

Due to the lack of data it is not possible to estimate a PEC/PNEC value and therefore the risk of environmental impact cannot be excluded.

Author: Health and Medical Care Administration, Region Stockholm