Proguanil
Summary
Persistence. Proguanil is potentially persistent
Bioaccumulation. Proguanil has low potential for bioaccumulation.
Toxicity. Proguanil has moderate chronic toxicity.
Risk. The use of proguanil (sales data Sweden 2020) has been considered to result in insignificant environmental risk.
This summary information comes from fass.se.
Detailed information
Fass environmental information
Fass environmental information for proguanil from Malarone Junior (atovaquone, proguanil), GlaxoSmithKline AB (retrieved on 2026-04-15).
Excretion (metabolism)
"Between 40% to 60% of proguanil is excreted by the kidneys. Proguanil is metabolized to cycloguanil (primarily via CYP2C19) and 4-chlorophenylbiguanide. The main routes of elimination are hepatic biotransformation and renal excretion."
The environmental information refers to proguanil.
Hazard
Persistence: Proguanil shows very low biotic degradation, with 4.03% degradation in 28 days in a ready biodegradability test (TAD 3.11) and less than 4% degradation in 28 days in an inherent biodegradability test (OECD 302B). No data are available for hydrolysis or photolysis. As proguanil is neither readily nor inherently biodegradable the phrase proguanil is potentially persistent in the environment is applied.
Bioaccumulation: Log Dow = 0.99 at pH 7 (TAD 3.02).
Toxicity: There are data for 3 trophic levels, most sensitive algae (Selenastrum capricornutum) NOEC 250 microg/L.
Risk
PEC/PNEC is based on sales data in Sweden in year 2020.
PEC = 0.012 microg/L.
PNEC = Lowest NOEC, 250 microg/L/50 (Assessment Factor (AF) for 2 chronic studies) = 5 microg/L.
PEC/PNEC = 0.0025 which gives the risk insignificant.
References
Author: Health and Medical Care Administration, Region Stockholm