Hazard 4 P 3 B 0 T 1 Risk Low
The T-value in the score for hazard refers to chronic toxicity. The data on hazard and risk are based on previous environmental information on Fass.se. Environmental information is missing on fass.se (2020-05-05). It is voluntary for manufacturers to provide information about environmental impact on fass.se.
Assessment report for Diprivan (propofol) (downloaded 2011-05-24).
Persistence OECD guideline 301F: "The results showed that propofol is not biodegradable, with <5% biodegradation after 28 days. However, >91% removal of propofol from the aqueous phase was observed, which was noted at the time as being possibly due to adsorption to the solid phase.
ISO Guideline 11734: The results showed that propofol was not biodegradable under the anaerobic conditions of the test, although a degree of elimination was observed.
The medicine is potentially persistent."
Bioaccumulation: "Log P = 3.9 (at pH 8). BCF 28 D = 27 (at 2 μg/L) and 28 D = 26 (at 0.2 μg/L)."
Toxicity: There are data for 3 trophic levels, most sensitive crustacean (Daphnia magna) NOEC chronic toxicity 230 microg/L.
PEC/PNEC is based on sales data in Sweden in year 2009. PEC/PNEC = 0,16 which gives the risk low.
Propofol is listed as readily biodegradable.
Author: Health and Medical Care Administration, Region Stockholm