The data on hazard and risk are based on previous environmental information on fass.se (2013-08-16). Environmental information is missing on fass.se (2021-12-08). It is voluntary for manufacturers to provide information about environmental impact on fass.se.
Persistence. Remifentanil is slowly degraded in the environment..
Bioaccumulation. Remifentanil has low potential for bioaccumulation.
Toxicity. Remifentanil has moderate acute toxicity.
Risk. Risk of environmental impact cannot be excluded, since there is not sufficient ecotoxicity data available.
Fass environmental information for Ultiva (remifentanil) from GlaxoSmithKline (downloaded 2013-08-16).
Persistence: "Results of biological degradation:
Ready biodegradation = 4% in 28 d (OECD 301, Jenkins 1994). The substance is not readily biodegradable.
Results of abiotic degradation:
Remifentanil is hydrolytically unstable under environmental
Half-Life at pH 7, 9.5 Hours, (FDA TAD 3.09, Colwyn 1994)
Half-Life at pH 5, 21.3 Days,
Half-Life at pH 9, 3.5 Hours."
Bioaccumulation: "Log Powcalculated = 1,36 at pH7 (TAD 3.02, Colwyn 1994)."
Toxicity: There are data for 1 trophic level, crustacean (Daphnia magna) EC50 48h > 360 000, microg/L (OECD 202, Jenkins 1994). Comment: Values reported as greater than are not according to the guidelines. The actual value may be lower.
Risk of environmental impact cannot be excluded, since there is not sufficient ecotoxicity data available.
Author: Health and Medical Care Administration, Region Stockholm