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Persistence. Sumatriptan is potentially persistent.

Bioaccumulation. Sumatriptan has low potential for bioaccumulation.

Toxicity. Sumatriptan has low chronic toxicity.

Risk. The use of sumatriptan (sales data Sweden 2019) has been considered to result in insignificant environmental risk.


This summary information comes from Fass.

Detailed information

Fass environmental information

Fass environmental information for Imigran (sumatriptan) from GlaxoSmithKline (downloaded 2023-02-06).


Persistence: "Ready degradability: 1% degradation in 28 days (OECD 301). Inherent degradability: 17% ultimate (DOC) degradation in 28 days (OECD 302B). 100% primary (parent) degradation in 16 days. This may be regarded as evidence for inherent primary biodegradation. This substance is not inherently biodegradable. Aerobic Degradation in Soil: 32.1%–40.2% degradation in 64 days (TAD 3.12). [---] The phrase “Sumatriptan is potentially persistent” is thus chosen."

Bioaccumulation: Log Dow = -2.3 at pH 7.

Chronic toxicity: There are data for 3 trophic levels, most sensitive green algae (Scenedesmus subspicatus) NOEC 12 500 microg/L.


PEC/PNEC is based on sales data in Sweden in year 2019. PEC/PNEC = 0.000164 which gives the risk insignificant.

Author: Health and Medical Care Administration, Region Stockholm