Hazard 3 P 3 B 0 T 0 Risk Insignificant
The T-value in the score for hazard refers to chronic toxicity. Underlying data for P, B, T and risk are from Fass.
Fass environmental information for Imigran (sumatriptan) (downloaded 2019-02-07).
Persistence: "Ready degradability: 1% degradation in 28 days (OECD 301). Inherent degradability: 17% ultimate (DOC) degradation in 28 days (OECD 302B). 100% primary (parent) degradation in 16 days. This may be regarded as evidence for inherent primary biodegradation. This substance is not inherently biodegradable. Aerobic Degradation in Soil: 32.1% - 40.2% degradation in 64 days (TAD 3.12). [---] The phrase “Sumatriptan is potentially persistent” is thus chosen."
Bioaccumulation: Log Dow = -2.3 at pH 7.
Toxicity: There are data for 3 trophic levels, most sensitive green algae (Scenedesmus subspicatus) NOEC 12 500 microg/L.
PEC/PNEC is based on sales data in Sweden in year 2015. PEC/PNEC = 0.000164 which gives the risk insignificant.
Author: Health and Medical Care Administration, Region Stockholm