Tapentadol
Summary
Persistence. Tapentadol is slowly degraded in the environment.
Bioaccumulation. Tapentadol has low potential for bioaccumulation.
Toxicity. Tapentadol has moderate chronic toxicity.
Risk. The use of tapentadol (sales data Sweden 2017) has been considered to result in insignificant environmental risk.
This summary information comes from fass.se.
Detailed information
Fass environmental information
Fass environmental information for Palexia (tapentadol) (downloaded 2019-04-25).
Hazard
Persistence: OECD Guideline 308 och bland annat "DT50 for the aerobic primary degradation of [14C]tapentadol in the water/sediment test systems ranged from 41 days to 126 days. [...] DT50 for the anaerobic primary degradation of [14C]tapentadol in the water/sediment test systems ranged from 51 days to 60 days." See additional data for OECD 308 in the environmental information for Palexia. "The phrase ‘Tapentadol is slowly degraded in the environment’ is chosen."
Bioaccumulation: "Log Kow for tapentadol is 2.89 ... which is below 4."
Toxicity: There are data for 3 trophic levels, most sensitive fish NOEC (Pimephales promelas) OECD 210 = 530 microg/L.
Risk
PEC/PNEC is based on sales data in Sweden in year 2017. PEC/PNEC = 0.00077432 which gives the risk insignificant.
References
Author: Health and Medical Care Administration, Region Stockholm