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Terbinafine

Summary

Persistence. Terbinafine is degraded in the environment.
Bioaccumulation. Terbinafine has high potential for bioaccumulation.
Toxicity. Terbinafine has very high chronic toxicity.
Risk. The use of terbinafine (sales data Sweden 2020) has been considered to result in low environmental risk.

This summary information comes from Fass.

Detailed information

Fass environmental information for Lamisil

Fass environmental information for Lamisil (terbinafine) from Novartis (downloaded 2022-06-30).

Hazard

Persistence: "DT50 (total system) = 16–31 days (OECD 308, 101 days). ... The phrase ‘The substance is degraded in the environment’ is chosen."

Bioaccumulation: Log P 5.2 (22.0 °C, OECD107).

Chronic toxicity: There is NOEC for 3 trophic levels, lowest NOEC for green algae (Pseudokirchneriella subspicata) 0.53 microg/L.

Risk

PEC/PNEC is based on sales data in Sweden in year 2020. PEC/PNEC = 0.73 which gives the risk low.

Fass environmental information for Lamisil Dermgel

Fass environmental information for Lamisil Dermgel (terbinafine) from GlaxoSmithKline (downloaded 2022-06-30).

Hazard

Persistence: "DT50 (total system) = 16–31 days. ... Therefore the phrase ‘The substance is degraded in the environment’ is thus chosen."

Bioaccumulation: Log P 5.2 (22.0 °C, OECD107). BCF calculated: 5248.

Chronic toxicity: There is NOEC for 3 trophic levels, lowest NOEC for green algae (Pseudokirchneriella subspicata) 0.53 microg/L.

Risk

PEC/PNEC is based on sales data in Sweden in year 2019. PEC/PNEC = 1.77 which gives the risk moderate.

Author: Health and Medical Care Administration, Region Stockholm