Terbinafine
Summary
Persistence. Terbinafine is degraded in the environment.
Bioaccumulation. Terbinafine has high potential for bioaccumulation.
Toxicity. Terbinafine has very high chronic toxicity.
Risk. The use of terbinafine (sales data Sweden 2020) has been considered to result in low environmental risk.
This summary information comes from Fass.
Detailed information
Fass environmental information for Lamisil
Fass environmental information for Lamisil (terbinafine) from Novartis (downloaded 2022-06-30).
Hazard
Persistence: "DT50 (total system) = 16–31 days (OECD 308, 101 days). ... The phrase ‘The substance is degraded in the environment’ is chosen."
Bioaccumulation: Log P 5.2 (22.0 °C, OECD107).
Chronic toxicity: There is NOEC for 3 trophic levels, lowest NOEC for green algae (Pseudokirchneriella subspicata) 0.53 microg/L.
Risk
PEC/PNEC is based on sales data in Sweden in year 2020. PEC/PNEC = 0.73 which gives the risk low.
Fass environmental information for Lamisil Dermgel
Fass environmental information for Lamisil Dermgel (terbinafine) from GlaxoSmithKline (downloaded 2022-06-30).
Hazard
Persistence: "DT50 (total system) = 16–31 days. ... Therefore the phrase ‘The substance is degraded in the environment’ is thus chosen."
Bioaccumulation: Log P 5.2 (22.0 °C, OECD107). BCF calculated: 5248.
Chronic toxicity: There is NOEC for 3 trophic levels, lowest NOEC for green algae (Pseudokirchneriella subspicata) 0.53 microg/L.
Risk
PEC/PNEC is based on sales data in Sweden in year 2019. PEC/PNEC = 1.77 which gives the risk moderate.
References
Author: Health and Medical Care Administration, Region Stockholm