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Tiotropium bromide

Information

Underlying data for P, B and risk are from Fass's environmental information downloaded 2022-01-18. The T value comes from Fass's environmental information downloaded 2011-04-14.

Persistence. Tiotropium bromide is potentially persistent.
Bioaccumulation. Tiotropium bromide has low potential for bioaccumulation.
Toxicity. Tiotropium bromide has moderate acute toxicity.
Risk. Risk of environmental impact of tiotropium bromid cannot be excluded, since there is not sufficient ecotoxicity data available.

Detailed information

Fass environmental information (2022-01-18)

Fass environmental information for Spiriva (tiotropium bromide) from Boehringer Ingelheim (downloaded 2022-01-18).

Hazard

Persistence: "Tiotropium bromide is not readily biodegradable (OECD 301B). As tiotropium bromide did not pass the readily biodegradable test the phrase “Tiotropium bromide is potentially persistent” is used."

Bioaccumulation: log D = -2.28 at pH 7.4 (OECD 117).

Toxicity: No data.

Risk

"Environmental assessment was based on toxicity data; however as only one and not three different trophic levels were available (kan inte hitta några data, red. anm.), a valid PNEC could not be calculated. The phrase “Risk of environmental impact of tiotropium bromid cannot be excluded, since there is not sufficient ecotoxicity data available” is therefore used."

The manufacturer has on fass.se stated that data about the environmental impact is incomplete for the substance so that the environmental risk cannot be calculated. It is voluntary for manufacturers to provide information on the environmental impact on fass.se.

Fass environmental information (2011-04-14)

Toxicity from Fass environmental information for Spiriva (tiotropium bromide) from Boehringer Ingelheim and Pfizer (downloaded 2011-04-14).

Hazard

Toxicity: There are data for 1 trophic level, crustacean (Daphnia magna) > 69 000 microg/L. Comment: Values reported as greater than are not according to the guidelines. The actual value may be lower.

Author: Health and Medical Care Administration, Region Stockholm