Hazard 4* P 3 B 0 T 1* Risk Cannot be excluded
The T-value in the score for hazard refers to acute toxicity. Underlying data for P, B and risk are from Fass's environmental information downloaded 2020-01-16. The T value comes from Fass's environmental information downloaded 2011-04-14.
Below is Hazard and Risk from Fass environmental information for Spiriva (tiotropium bromide) from Boehringer Ingelheim (downloaded 2020-01-16).
Persistence: "Tiotropium bromide is not readily biodegradable (OECD 301B). As tiotropium bromide did not pass the readily biodegradable test the phrase “Tiotropium bromide is potentially persistent” is used."
Bioaccumulation: log D = -2.28 at pH 7.4 (OECD 117).
Toxicity: No data.
"Environmental assessment was based on toxicity data; however as only one and not three different trophic levels were available (kan inte hitta några data, red. anm.), a valid PNEC could not be calculated. The phrase “Risk of environmental impact of tiotropium bromid cannot be excluded, since there is not sufficient ecotoxicity data available” is therefore used."
Below is Hazard and Risk from Fass environmental information for Spiriva (tiotropium bromide) from Boehringer Ingelheim and Pfizer (downloaded 2011-04-14).
Toxicity: There are data for 1 trophic level, crustacean (Daphnia magna) > 69 000 microg/L.
Author: Health and Medical Care Administration, Region Stockholm