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Tiotropium bromide

Hazard 4* P 3 B 0 T 1* Risk Cannot be excluded

Information

The T-value in the score for hazard refers to acute toxicity. Underlying data for P, B and risk are from Fass's environmental information downloaded 2019-02-13. The T value comes from Fass's environmental information downloaded 2011-04-14.

Fass environmental information (2019-02-13)

Below is Hazard and Risk from Fass environmental information for Spiriva (tiotropium bromide) (downloaded 2019-02-13).

Hazard

Persistence: "Tiotropium bromide is not readily biodegradable (OECD 301B). As tiotropium bromide did not pass the readily biodegradable test the phrase “Tiotropium bromide is potentially persistent” is used."

Bioaccumulation: log D = -2.28 at pH 7.4 (OECD 117).

Toxicity: No data.

Risk

"Environmental assessment was based on toxicity data; however as only one and not three different trophic levels were available (kan inte hitta några data, red. anm.), a valid PNEC could not be calculated. The phrase “Risk of environmental impact of tiotropium bromid cannot be excluded, since there is not sufficient ecotoxicity data available” is therefore used."

Fass environmental information (2011-04-14)

Below is Hazard and Risk from Fass environmental information for Spiriva (tiotropium bromide) (downloaded 2011-04-14).

Hazard

Toxicity: There are data for 1 trophic level, crustacean (Daphnia magna) > 69 000 microg/L.

Author: The Pharmaceutical unit of Region Stockholm