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Hazard 5* P 3 B 0 T 2* Risk See below


According to EMA's assessment report, EMA / CHMP/853224/2016, tofacitinib is slowly degraded in the environment and has low potential for bioaccumulation. The T-value is usually based on data on acute toxicity, but since no information of acute toxicity is available, T has been calculated on the chronic toxicity, NOEC 2.9 mg/L for fish.

Environmental information for the substance is not available on fass.se. It is voluntary for manufacturers to publish environmental impact information on fass.se.

Author: Health and Medical Care Administration, Region Stockholm