Tolterodine
Summary
Persistence. It cannot be excluded that tolterodine is persistent, due to the lack of data.
Bioaccumulation. It cannot be excluded that tolterodine bioaccumulates, due to the lack of data.
Toxicity. It cannot be excluded that tolterodine is toxic, due to the lack of data.
Risk. Both ecotoxicological effect data and environmental measurements are limited for incontinence pharmaceuticals. However, excretion data, available ecotoxicological effect data, and risk assessment using the fish plasma model for both parent compounds and active metabolites consistently indicate a negligible environmental risk associated with the use of the three anticholinergic substances solifenacin, tolterodine, and fesoterodine from a Swedish perspective. For mirabegron, which is considered persistent in the environment, the risk is somewhat higher but still low. Therefore, no substitutions are recommended from an environmental risk perspective.
Environmental information is missing on fass.se for tolterodine (2026-01-16). The risk assessment is taken from the Goodpoint 2026 review.
Detailed information
Environmental assessment by Goodpoint 2026
Both ecotoxicological effect data and environmental measurements are limited for incontinence pharmaceuticals. However, excretion data, available ecotoxicological effect data, and risk assessment using the fish plasma model for both parent compounds and active metabolites consistently indicate a negligible environmental risk associated with the use of the three anticholinergic substances solifenacin, tolterodine, and fesoterodine from a Swedish perspective. For mirabegron, which is considered persistent in the environment, the risk is somewhat higher but still low. Therefore, no substitutions are recommended from an environmental risk perspective.
Author: Health and Medical Care Administration, Region Stockholm