The T-value in the score for hazard refers to acute toxicity. Underlying data for P, B, T and risk are from Fass.
Fass environmental information for Topimax (Topiramate) from Janssen (downloaded 2019-12-04).
Persistence: No data.
Bioaccumulation: Log Kow = 0.5 (pH = 6.0).
Toxicity: There are data for 3 trophic levels, most sensitive algae (Pseudokirchneriella subcapitata) 93 000 microg/L.
PEC/PNEC is based on sales data in Sweden in year 2016. PEC/PNEC = 0.000411709 which gives the risk insignificant.
Author: Health and Medical Care Administration, Region Stockholm