Kommersiellt obunden läkemedelsinformation riktad till läkare och sjukvårdspersonal

Tramadol

Summary

Hazard - P - B - T - Risk See below

 

Environmental information for the substance is not available on Fass.se (2019-02-15). It is voluntary for manufacturers to publish environmental impact information on Fass.se.

Report Goodpoint 2016

Based on measured levels in surface water and fat solubility, it may be thought that tramadol can accumulate in fish at concentrations approaching therapeutic concentrations in humans, but actual measurements indicate significantly lower ability to bioconcentrate. Available efficacy data do not indicate any risk of environmental impact, but mechanism-based studies are lacking. Tramadol is highly persistent in the environment.

Pharmaceuticals in the aquatic environment

Tramadol has been detected in treated wastewater, raw water and drinking water in Stockholm County in the last five years (2012–2016). In 2017 tramadol was found in treated wastewater and drinking water.

Tramadol has been found in spiders

Tramadol was one of the top 5 most frequently detected pharmaceuticals in spiders (article Richmond et al. 2018).

References

  1. Goodpoint. Prioritering av läkemedel med miljörisk inom SLL. Stockholm: Goodpoint; 2016. Rapport LS 2016–0634.
  2. SLL. Sammanställning av läkemedelsprovtagningar - Bearbetning av regional försäljningsstatistik av läkemedel samt datamaterial från Stockholms läns landstings mätprogram för läkemedelssubstanser i vattenmiljö, 2012–2016.
  3. IVL Swedish Environmental Research Institute Ltd. Fick J, Lindberg RH, Kaj L, Brorström-Lundén E. Results from the Swedish National Screening Programme 2010. Subreport 3, B 2014 Pharmaceuticals.
  4. IVL Swedish Environmental Research Institute Ltd Fick J, Lindberg RH, Fång J, Magnér J, Kaj L, Brorström-Lundén E. Screening 2014. Analysis of pharmaceuticals and hormones in samples from WWTPs and receiving waters. Rapport C 135.
  5. Bergheim M, Gieré R, Kümmerer K. Biodegradability and ecotoxicitiy of tramadol, ranitidine, and their photoderivatives in the aquatic environment. Environ Sci Pollut Res Int. 2012;19:72-85.
  6. Fick J, Lindberg RH, Tysklind M, Larsson DG. Predicted critical environmental concentrations for 500 pharmaceuticals. Regul Toxicol Pharmacol. 2010;58:516-23.
  7. Stockholm Vatten. Läkemedelsrester i Stockholms vattenmiljö. 2010. ISBN 978-91-633-6642-0.
  8. Richmond EK, Rosi EJ, Walters DM, Fick J, Hamilton SK, Brodin T et al. A diverse suite of pharmaceuticals contaminates stream and riparian food webs. Nat Commun. 2018;9(1):4491.

Author: Health and Medical Care Administration, Region Stockholm