Environmental information for the substance is not available on Fass.se (2019-02-15). It is voluntary for manufacturers to publish environmental impact information on Fass.se.
Based on measured levels in surface water and fat solubility, it may be thought that tramadol can accumulate in fish at concentrations approaching therapeutic concentrations in humans, but actual measurements indicate significantly lower ability to bioconcentrate. Available efficacy data do not indicate any risk of environmental impact, but mechanism-based studies are lacking. Tramadol is highly persistent in the environment.
Tramadol has been detected in treated wastewater, raw water and drinking water in Stockholm County in the last five years (2012–2016). In 2017 tramadol was found in treated wastewater and drinking water.
Tramadol was one of the top 5 most frequently detected pharmaceuticals in spiders (article Richmond et al. 2018).
Author: The Pharmaceutical unit of Region Stockholm