Valaciclovir

Information

The T-value in the score for hazard refers to chronic toxicity. Underlying data for P, B, T and risk are from Fass.

Fass environmental information

Fass environmental information for Valtrex (valaciclovir) (downloaded 2019-02-08).

"Valaciclovir is a pro-drug which is fully metabolised to the active pharmaceutical ingredient Aciclovir. As a result this assessment is based on aciclovir."

Hazard

Persistence: "Hydrolysis: Half-life, pH 7 > 1 year (TAD 3.09). Photolysis: Half-life, pH 7 = 3.5 hours (TAD 3.10). Aciclovir is not readily biodegradable nor inherently biodegradable. The phrase “Aciclovir is potentially persistent” is thus chosen."

Bioaccumulation: Log Pcalc = -1.55.

Toxicity: There are data for 3 trophic levels, most sensitive crustacean (Daphnia magna) NOEC 10 000 microg/L.

Risk

PPEC/PNEC is based on sales data in Sweden in year 2016. PEC/PNEC = 0.0019 which gives the risk insignificant.