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Valproic acid


Hazard 4 P 3 B 0 T 1 Risk Insignificant


The T-value in the score for hazard refers to acute toxicity. Underlying data for P, B, T and risk are from Fass.

Fass environmental information

Fass environmental information for Ergenyl Retard (valproic acid) (downloaded 2018-11-15).


Persistence according to "Ready biodegradability: Test showed 48 % degradation in 28 days (OECD 301). Valproic acid fails to pass the criteria for ready biodegradability. The phrase "Valproic acid is potentially persistent" is thus chosen."

Bioaccumulation: Log Kow = 2.60 at pH 7 (OECD 107).

Acute toxicity: There are data for 3 trophic levels, lowest for fish (Danio rerio) 66 000 microg/L.


PEC/PNEC is based on sales data in Sweden in year 2016. PEC/PNEC = 0.004 which gives the risk insignificant.

Author: Health and Medical Care Administration, Region Stockholm