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Valproic acid


Persistence. Valproic acid is potentially persistent.

Bioaccumulation. Valproic acid has low potential for bioaccumulation.

Toxicity. Valproic acid has low chronic toxicity.

Risk. The use of valproic acid (sales data Sweden 2019) has been considered to result in insignificant environmental risk.


This summary information comes from Fass.

Fass environmental information

Fass environmental information for Ergenyl Retard (valproic acid) from Sanofi AB (downloaded 2023-10-24).


Persistence according to "Ready biodegradability: Test showed 48 % degradation in 28 days (OECD 301). Valproic acid fails to pass the criteria for ready biodegradability. The phrase "Valproic acid is potentially persistent" is thus chosen."

Bioaccumulation: Log Kow = 2.60 at pH 7 (OECD 107).

Acute toxicity: There are data for 3 trophic levels, lowest for crustacean (Daphnia magna) ≥ 8870 microg/L.

Comment: Values reported as greater than are not according to the guidelines. The actual value may be lower.


PEC/PNEC is based on sales data in Sweden in year 2019. PEC/PNEC = 0.00028 which gives the risk insignificant.

Author: Health and Medical Care Administration, Region Stockholm