Hazard 9* P 3 B 3 T 3* Risk Insignificant
The T-value in the score for hazard refers to chronic toxicity. Underlying data for T comes from scientific discussion for Champix (varenicline), see below. Underlying data for P, B and risk comes from Fass environmental information for Champix, see below.
Scientific discussion for Champix (varenicline) 11/10/2006.
Persistence: No data. "Varenicline did not meet the criteria for PBT/PvBv substances."
Bioaccumulation: No data. "Varenicline did not meet the criteria for PBT/PvBv substances."
Chronic toxicity: There is NOEC for 1 trophic level, crustacean (Ceriodaphnia dubia) 0.003 mg/L.
The risk, PEC/PNEC, from the scientific discussion from a European perspective:
PEC = 0.01 microg/L.
PEC/PNEC = 0.03.
Fass environmental information for Champix (downloaded 2011-05-27).
Persistence: The substance breaks down slowly in the environment.
Bioaccumulation: The substance has the potential to be accumulated in aquatic organisms.
Toxicity: There are data for 3 trophic levels, most sensitive crustacean (Ceriodaphnia Dubia) "7-day NOEC of 2.7 ug/L"
PEC/PNEC is based on sales data in Sweden, which year is not stated. PEC/PNEC = 0.007 which gives the risk insignificant.
Author: Health and Medical Care Administration, Region Stockholm